I tried, and increased the blade depth ... and broke the blade very quickly ! And of course I did not (at the time) have spare blades !
If you do, keep the blade depth as small as possible, and choose multiple passes. Very likely, you will score the plastic more than completely cut through it, but this is what we do most of the time with a #11 blade anyway ...
If you want to cut through thicker materials, then the Curio is better than the Portrait. it is more limited in terms of size of the sheets it will accept, but that should not be an issue for most work.